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Description
IL-13 His Tag Protein, HumanProduct Specification Species Human Synonyms ALRH, BHR1, MGC116786, MGC116788, P600, Interleukin 13 Accession AAK53823. 1 Amino Acid Sequence Gly21 Asn132 with His Tag at the C Terminus Expression System HEK293 Molecular Weight 25 40kDa (Reducing) Purity 90% by SDS PAGE & HPLC Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized powder Storage Buffer PBS, PH7. 4, 5% trehalose Reconstitution Reconstitute at 0. 1 1 mg ml according to the
Product Specification
| Species | Human |
| Synonyms | ALRH, BHR1, MGC116786, MGC116788, P600, Interleukin-13 |
| Accession | AAK53823.1 |
| Amino Acid Sequence | Gly21-Asn132 with His Tag at the C-Terminus |
| Expression System | HEK293 |
| Molecular Weight | 25-40kDa (Reducing) |
| Purity | ＞90% by SDS-PAGE & HPLC |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized powder |
| Storage Buffer | PBS, PH7.4, 5% trehalose |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. |
| Reference | 1.Castro M, Corren J, Pavord ID, Maspero J, Wenzel S, Rabe KF, Busse WW, Ford L, Sher L, FitzGerald JM, Katelaris C, Tohda Y, Zhang B, Staudinger H, Pirozzi G, Amin N, Ruddy M, Akinlade B, Khan A, Chao J, Martincova R, Graham NMH, Hamilton JD, Swanson BN, Stahl N, Yancopoulos GD, Teper A. Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma. N Engl J Med. 2018 Jun 28;378(26):2486-2496. |
Background
IL-13 (interleukin 13) is a type I cytokine secreted by activated Th2 cells, mast cells, and basophils, belonging to the four-helix bundle cytokine family. Its protein structure consists of four α-helices (A, B, C, D) stabilized by two disulfide bonds forming a compact globular conformation, and recombinant expression with His-tag technology facilitates purification and structural studies. This cytokine activates the JAK1/TYK2-STAT6 signaling pathway through type I receptors (IL-13Rα1/IL-4Rα heterodimer), regulating B cell IgE class switching, mucus production, and eosinophil chemotaxis; concurrently, binding to IL-13Rα2 (decoy receptor) participates in inflammatory modulation and tissue fibrosis. In clinical medicine, IL-13 serves as a core driver of type 2 inflammatory diseases, with biologics targeting the IL-4/IL-13 pathway such as dupilumab approved for treating moderate-to-severe asthma, atopic dermatitis, and chronic rhinosinusitis with nasal polyps. Furthermore, IL-13 receptor α2 is highly expressed in solid tumors including glioblastoma, emerging as a novel tumor target for CAR-T cells and bispecific antibodies, demonstrating broad clinical application prospects spanning from inflammatory regulation to cancer immunotherapy.
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